WRAP53 antibody

Catalog No. ABIN7120809

This anti-WRAP53 antibody is a Rabbit Polyclonal antibody detecting WRAP53 in WB, IHC, ELISA and IP. Suitable for Human, Mouse and Rat.

Quick Overview for WRAP53 antibody (ABIN7120809)

Target: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WRAP53 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-WRAP53 Antibody

Purpose: WRAP53 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: WD repeat containing, antisense to TP53

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200, IP: 1:200-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for WRAP53

Target: WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))

Alternative Name: WRAP53

Background:

Synonyms: Telomerase Cajal body protein 1|WD repeat-containing protein 79|WD40 repeat-containing protein antisense to TP53 gene (WRAP53beta)|WRAP53|TCAB1|WDR79

Background: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs(scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level, it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Molecular Weight: 72 kDa

Gene ID: 55135

UniProt: Q9BUR4

Pathways: Telomere Maintenance